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Min J, Zhang X, Cheng X, Grewal SI, Xu RM: Construction of the SET domain histone lysine methyltransferase Clr4. In both proteins, the walls of the lysine-binding channel are fashioned by hydrophobic residues that engage in van der Waals interactions with the lysine aspect chain (Determine 4b,c ). At the base of the channel is the methyltransfer pore, which connects the pocket to the AdoMet-binding cleft.
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