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reference.comThe statistics are eye opening: one out of three girls and one out of 4 males are on a weight-reduction plan at any given time. The exception to the rule is the DOT1 household, members of which methylate K79 in the globular area of histone H3 and which are structurally not associated to SET-domain proteins four - 6 Latest work means that SET-domain-containing proteins methylate a couple of proteins in addition to histones (see later)