Following the early January 1967 Exercise "Snatch Block," which was dedicated to SAR and digital countermeasure (ECM) procedures, Berkeley spent the following three months preparing for another Far East deployment. USS Biddle was deployed to the Middle East in September 1990 as a part of Operation Desert Shield, the place she joined the Saratoga battle group on the Red Sea. During the primary 5 months of the year, Biddle operated along the east coast and in the West Indies. During the following three months, Biddle operated out of her home port both within the Virginia Capes working area and Mitolyn Benefits in the West Indies. On 4 February, she stood out of Chesapeake Bay on her option to refresher coaching within the West Indies. The guided-missile destroyer carried out native operations by April 1968 before transferring into Long Beach Naval Shipyard for a maintenance overhaul. The guided-missile cruiser completed put up-deployment standdown in mid-January 1983 and resumed operations out of her house port. Back within the Mediterranean on four September, she resumed regular sixth Fleet operations-multiship workouts and port visits.

On 26 May, the warship put to sea for NATO Exercise "United Effort/ Ocean Safari 83." At the conclusion of that exercise, she commenced a series of port visits alternated with operations within the Baltic Sea. Upon leaving the shipyard on 25 August, the warship commenced a 3-month missile development check and evaluation program. Following the removal of check equipment in mid-December, the guided missile destroyer spent the remainder of the month preparing for upcoming fleet workouts. Following a tender availability at Kaohsiung, Taiwan, the guided-missile destroyer returned to the gunline on 22 September. During this period, her engineers and technicians busied themselves sustaining and enhancing the warship's complicated digital and fireplace-control systems, a task abetted by a 3-week tender availability in early February. The duty unit cruised off North Vietnam near Hon Me and Hon Matt Islands, looking for enemy waterborne logistics craft and firing on designated targets ashore. During armistice, the analysis flight is designated as INA.

In firm with the destroyer Arnold J. Isbell, Berkeley coordinated rescue helicopter flights, and people of fighter aircraft from the carriers Ranger and Kitty Hawk, as the two warships closed the ditch site. Meisner, Arnold (1991). Desert Storm: Sea War. Then again, as highlighted in (Finke et al., 1996